Metabolic inflexibility promotes mitochondrial health during liver regeneration.

(Wang et al. 14 Jun 2024)

Suppressed acetyl-CoA production promotes mitochondrial health during liver regeneration.

During liver injury and regeneration, fatty acids from adipose tissues transit to the liver to fuel mitochondrial beta oxidation in WT hepatocytes, which outcompete ETC-mutant hepatocytes. In the absence of a functional ETC, fatty acid buildup reduces acetyl-CoA thr…