New Research Shows Why Genetic Studies Rank Genes Differently

Spence et al. (2025)

A large-scale analysis of genetic data from more than 200 traits in the UK Biobank is shedding new light on why different gene-mapping methods often produce conflicting results. The study, published in Nature on 5 November 2025, reveals that genome-wide association studies (GWAS) and rare-variant burden tests systematically prioritize distinct sets of g…