Why Some People Don’t Respond to Exercise: Gut–Fat Crosstalk Identified as Key Metabolic Switch
research from Wang et al. (2025)
A new study published in Cell Metabolism has uncovered a molecular mechanism that explains why exercise substantially improves metabolic health in some individuals but produces limited benefits in others. The findings point to an unexpected player in exercise responsiveness: adipocyte-derived soluble IL-6 receptor (sIL-6R), a molecule regulated by the g…